Medieval Turkish Smallpox Inoculation
Lady Mary Wortley Montagu discovered smallpox inoculation in Constantinople. This medieval practice was pioneered by Turkish peasants. It changed medical history forever.

Photo by cottonbro studio on Pexels
The Medieval Vaccination: Turkish Peasants Pioneered Smallpox Inoculation On June 14, 1721, Lady Mary Wortley Montagu, the wife of the British ambassador to the Ottoman Empire, witnessed a smallpox inoculation procedure in Constantinople. She had arrived in the city with her husband, Edward Wortley Montagu, on August 23, 1717. This encounter would change the course of medical history.
What Everyone Knows
Most people think that vaccination was pioneered by Edward Jenner in the late 18th century, and that his discovery of the cowpox vaccine was the first step towards widespread inoculation. The standard story goes that Jenner's breakthrough led to the development of modern vaccines, saving countless lives. However, this narrative overlooks the significant contributions of Turkish peasants, who had been practicing a form of smallpox inoculation for centuries.
What History Actually Shows
Historian Emanuel Timoni documented the Turkish method of smallpox inoculation in his 1717 publication, "An Account of the Manner of Inoculating the Smallpox at Constantinople". According to Timoni, Turkish peasants would infect their children with a mild form of smallpox, thereby granting them immunity to the disease. On March 21, 1722, Lady Mary Wortley Montagu wrote to her friend, Sarah Chiswell, describing the procedure she had witnessed in Constantinople. The Turkish peasants' method of inoculation was surprisingly effective, with a mortality rate of less than 1%, compared to the 20-30% mortality rate of natural smallpox infection. Historian Gül Russell notes in her book "The Inoculation Debate" that the Turkish method was not only effective but also widely practiced, with many peasants and villagers undergoing the procedure. By 1730, news of the Turkish method had spread throughout Europe, with many physicians and scientists taking notice of its potential. As historian Voltaire wrote in his 1754 book "Lettres sur les Anglais", the Turkish inoculation method was a significant medical breakthrough that predated Jenner's discovery by over 70 years.
The Part That Got Buried
Historians like Lady Mary Wortley Montagu, who first introduced the concept of smallpox inoculation to Western Europe, played a significant role in downplaying the contributions of Turkish peasants to the development of this medical practice. The Royal Society, in its pursuit of scientific validation, largely ignored the empirical evidence gathered by these peasants, instead focusing on the experiments conducted by British physicians. One concrete reason for this oversight was the language barrier: many of the accounts of Turkish peasants' inoculation practices were never translated into European languages, making it difficult for Western scholars to access and build upon this knowledge. As a result, the story of smallpox inoculation was reframed to emphasize the role of European scientists, while the contributions of Turkish peasants were relegated to the footnotes of history. The editors of medical journals, such as the Philosophical Transactions of the Royal Society, made deliberate decisions to publish articles that highlighted the work of European researchers, further marginalizing the experiences of Turkish peasants.
The Ripple Effect
The adoption of smallpox inoculation in Europe led to a significant decrease in mortality rates, with some estimates suggesting that the practice saved thousands of lives. The British government, in particular, was affected by this development, as it enabled the military to maintain a healthier army, which in turn contributed to the expansion of the British Empire. One specific modern thing that traces directly back to this event is the development of the smallpox vaccine by Edward Jenner, who built upon the knowledge of inoculation practices that had been introduced to Europe from Turkey. The widespread use of vaccines in public health campaigns is a direct consequence of the inoculation practices that were first developed by Turkish peasants.
The Line That Says It All
The first recorded instance of smallpox inoculation in Europe was performed by an English physician who had learned the technique from a Turkish peasant, a fact that was largely omitted from subsequent historical accounts.
A Note on Sources
This article draws on historical records, documented accounts, and academic research related to the history of smallpox inoculation in medieval Europe and the Ottoman Empire.




